BDBM497327 US11001595, Compound 1::US11001595, Compound 5::US11111252, Compound 1

SMILES COc1ccc(Sc2sc3nc(N)nc(N)c3c2C)cc1OC

InChI Key InChIKey=YOJLXUCTDDKMGX-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 497327   

TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  260nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  3.90E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  6.90E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Human pneumocystis pneumonia agent)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  260nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  910nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Human pneumocystis pneumonia agent)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  3.90E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  6.90E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  910nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent